You have a OPC UA server running in a Python, which needs to connect to the OPC UA client in Visual Components. Can you connect? Does the server structure appear in the Create Variable Pairs editor in VC for the server connection? See the above examples on what others had to do for the connection to work.
You want to pair variables from the server with variables in your simulation, e.g. layout of components in 3D world. And then what: Are the simulation variables such as signal or property supposed to call functions when their values change? I ask because it is not clear if you want a component script to start and stop simulation or if you plan on using .NET API.